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Research on Methamphetamine

The methamphetamine literature review provides a list of peer-reviewed research citations about methamphetamine, separated into sections by specific topical areas; prenatal methamphetamine exposure, children and family affected by methamphetamine use, prevalence, intervention and treatment, criminal justice and legislation, tribal populations and methamphetamine issues and military and veteran families and children impacted by methamphetamine.

Prenatal Methamphetamine Exposure

Abar, B., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., Smith, L. M., ... & Lester, B. M. (2013). Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition. Psychology of Addictive Behaviors, 27(3), 662. doi: 10.1037/a0030157

Colby, J. B., Smith, L., O'Connor, M. J., Bookheimer, S. Y., Van Horn, J. D., & Sowell, E. R. (2012). White matter microstructural alterations in children with prenatal methamphetamine/polydrug exposure. Psychiatry Research: Neuroimaging, 204(2), 140- 148. doi:10.1016/j.pscychresns.2012.04.017

Derauf, C., LaGasse, L. L., Smith, L. M., Newman, E., Shah, R., Neal, C. R., Arria, A. M., Huestis, M. A., Della Grotta, S., Dansereau, L.M., Lin, H., & Lester, B.M. (2012). Prenatal methamphetamine exposure and inhibitory control among young school-age children. Journal of Pediatrics, 161(3), 452–459. doi: 10.1016/j.jpeds.2012.02.002

Diaz, S. D., Smith, L. M., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., ... & Lester, B. M. (2014). Effects of prenatal methamphetamine exposure on behavioral and cognitive findings at 7.5 years of age. The Journal of Pediatrics. doi: 10.1016/j.jpeds.2014.01.053

Himes, S. K., LaGasse, L. L., Derauf, C., Newman, E., Smith, L. M., Arria, A. M., ... & Huestis, M. A. (2014). Risk of neurobehavioral disinhibition in prenatal methamphetamine- exposed young children with positive hair toxicology results. Therapeutic drug monitoring. doi: 10.1097/FTD.0000000000000049

Kiblawi, Z. N., Smith, L. M., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., ... & Lester, B. (2013). The effect of prenatal methamphetamine exposure on attention as assessed by Continuous Performance Tests: Results from the Infant Development, Environment, and Lifestyle (IDEAL) Study. Journal of developmental and behavioral pediatrics: JDBP, 34(1), 31. doi:10.1097/DBP.0b013e318277a1c5

Kirlic, N., Newman, E., LaGasse, L. L., Derauf, C., Shah, R., Smith, L. M., ... & Lester, B. M. (2013). Cortisol reactivity in two-year-old children prenatally exposed to methamphetamine. Journal of studies on alcohol and drugs, 74(3), 447. Retrieved from

LaGasse, L. L., Derauf, C., Smith, L. M., Newman, E., Shah, R., Neal, C., ... & Lester, B. M. (2012). Prenatal methamphetamine exposure and childhood behavior problems at 3 and 5 years of age. Pediatrics, 129(4), 681-688. doi: 10.1542/peds.2011-2209

LaGasse, L. L., Wouldes, T., Newman, E., Smith, L. M., Shah, R. Z., Derauf, C., ... & Lester, B. M. (2011). Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand.Neurotoxicology and teratology, 33(1), 166-175. doi: 10.1016/

Lindsay, B., Albrecht, J., & Terplan, M. (2011). Against professional advice: Treatment attrition among pregnant methamphetamine users. Substance abuse and rehabilitation, 2, 189. doi: 10.2147/SAR.S25083

Lu, L. H., Johnson, A., O’Hare, E. D., Bookheimer, S. Y., Smith, L. M., O’Connor, M. J., & Sowell, E. R. (2009). Effects of prenatal methamphetamine exposure on verbal memory revealed with fMRI. Journal of developmental and behavioral pediatrics: JDBP, 30(3), 185. doi: 10.1097/DBP.0b013e3181a7ee6b

Moore, D. G., Turner, J. J., Goodwin, J. E., Fulton, S. E., Singer, L. T., & Parrott, A. C. (2011). In-utero exposure to the popular ‘recreational’ drugs MDMA (ecstasy) and methamphetamine (ice, crystal): preliminary findings. In Preece, P. & Riley, E. (Eds.), Alcohol, Drugs and Medication in Pregnancy: The Outcome For The Child. Retrieved from (PDF 8KB)

Roos, A., Jones, G., Howells, F. M., Stein, D. J., & Donald, K. A. (2014). Structural brain changes in prenatal methamphetamine-exposed children. Metabolic brain disease, 1-9. doi: 10.1007/s11011-014-9500-0

Roussotte, F. F., Rudie, J. D., Smith, L., O’Connor, M. J., Bookheimer, S. Y., Narr, K. L., & Sowell, E. R. (2012). Frontostriatal connectivity in children during working memory and the effects of prenatal methamphetamine, alcohol, and polydrug exposure. Developmental neuroscience, 34(1), 43-57. doi: 10.1159/000336242

Siegel, J. A., Park, B. S., & Raber, J. (2011). Methamphetamine exposure during brain development alters the brain acetylcholine system in adolescent mice. Journal of neurochemistry, 119(1), 89-99. doi:10.1111/j.1471-4159.2011.07418.x

Thompson, B. L., Levitt, P., & Stanwood, G. D. (2009). Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nature Reviews Neuroscience, 10(4), 303-312. doi: 10.1038/nrn2598

Children and Families Affected by Methamphetamine

Asanbe, C. B., Hall, C., & Bolden, C. (2012). Mental health disorders in children of non-drug- abusing parents A sample from a rural community devastated by methamphetamine. Journal of Child Health Care, 16(1), 15-25. doi: 10.1177/1367493511420182

Brensilver, M., Heinzerling, K. G., & Shoptaw, S. (2013). Pharmacotherapy of amphetamine‐ type stimulant dependence: An update. Drug and alcohol review, 32(5), 449-460. doi: 10.1111/dar.12048

Carlson, B. E., Williams, L. R., & Shafer, M. S. (2012). Methamphetamine-involved parents in the child welfare system: Are they more challenging than other substance-involved parents?. Journal of Public Child Welfare, 6(3), 280-295. doi: 10.1080/15548732.2012.683361

Caroner-Lopez, K., Owens, J.G., & Miller, J. (2012). Women’s “storylines” of methamphetamine initiation in the Midwest. Journal of Drug Issues, 42(3), 226– 246. doi: 10.1177/0022042612456013

Carroll Chapman, S. L., & Wu, L. T. (2013). Substance use among adolescent mothers: A review. Children and youth services review, 35(5), 806-815. Retrieved from

Castaneto, M. S., Barnes, A. J., Scheidweiler, K. B., Schaffer, M., Rogers, K. K., Stewart, D., & Huestis, M. A. (2013). Identifying methamphetamine exposure in children. Therapeutic drug monitoring, 35(6), 823-830. doi: 10.1097/FTD.0b013e31829685b2

Chomchai, C., & Manaboriboon, B. (2012). Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children. Journal of Medical Toxicology, 8(3), 291-294. doi: 10.1007/s13181-012-0228-0

Grant, P., Bell, K., Stewart, D., Paulson, J., & Rogers, K. (2010). Evidence of methamphetamine exposure in children removed from clandestine methamphetamine laboratories. Pediatric emergency care, 26(1), 10-14. doi: 10.1097/PEC.0b013e3181c33085

Haight, W., Marshall, J., Hans, S., Black, J., & Sheridan, K. (2010). “They mess with me, I mess with them”: Understanding physical aggression in rural girls and boys from methamphetamine-involved families. Children and youth services review, 32(10), 1223-1234. doi: 10.1016/j.childyouth.2010.04.010

Hawkrigg, S. L., & Winterton, P. M. (2013). Children and clandestine drug laboratories: The unseen victims. The Medical journal of Australia, 199(11), 739. doi: 10.5694/mja13.10684

Liles, B. D., Newman, E., LaGasse, L. L., Derauf, C., Shah, R., Smith, L. M., ... & Lester, B. M. (2012). Perceived child behavior problems, parenting stress, and maternal depressive symptoms among prenatal methamphetamine users. Child Psychiatry & Human Development, 43(6), 943-957. doi: 10.1007/s10578-012-0305-2

Lu, L. H., Johnson, A., O’Hare, E. D., Bookheimer, S. Y., Smith, L. M., O’Connor, M. J., & Sowell, E. R. (2009). Effects of prenatal methamphetamine exposure on verbal memory revealed with fMRI. Journal of developmental and behavioral pediatrics: JDBP, 30(3), 185. doi: 10.1097/DBP.0b013e3181a7ee6b

Marshall, B. D., & Werb, D. (2010). Health outcomes associated with methamphetamine use among young people: a systematic review. Addiction, 105(6), 991-1002. doi:10.1111/j.1360-0443.2010.02932.x

Messina, N., Marinelli-Casey, P., West, K., & Rawson, R. (2007). Children exposed to methamphetamine use and manufacture. Child abuse & neglect. doi: 10.1016/j.chiabu.2006.06.009

Messina, N., & Jeter, K. (2012). Parental methamphetamine use and manufacture: child and familial outcomes. Journal of public child welfare, 6(3), 296-312. doi:10.1080/15548732.2012.683364

Pennar, A.L., Shapiro, A.F., & Krysik, J. (2012). Drug endangered children: Examining children removed from methamphetamine laboratories. Children and Youth Services Review, 34, 1777–1785. doi:10.1016/j.childyouth.2012.05.006

Piper, B. J., Acevedo, S. F., Kolchugina, G. K., Butler, R. W., Corbett, S. M., Honeycutt, E. B., ... & Raber, J. (2011). Abnormalities in parentally rated executive function in methamphetamine/polysubstance exposed children. Pharmacology Biochemistry and Behavior, 98(3), 432-439. doi: 10.1016/j.pbb.2011.02.013

Semple, S. J., Strathdee, S. A., Zians, J., & Patterson, T. L. (2011). Methamphetamine-using parents: the relationship between parental role strain and depressive symptoms. Journal of studies on alcohol and drugs, 72(6), 954-964. Retrieved from

Sheridan, K., Haight, W. L., & Cleeland, L. (2011). The role of grandparents in preventing aggressive and other externalizing behavior problems in children from rural, methamphetamine-involved families. Children and youth services review, 33(9), 1583- 1591. doi: 10.1016/j.childyouth.2011.03.023

Smith, L. M., Paz, M. S., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., ... & Lester, B. M. (2012). Maternal depression and prenatal exposure to methamphetamine: neurodevelopmental findings from the infant development, environment, and lifestyle (ideal) study. Depression and anxiety, 29(6), 515-522. doi: 10.1002/da.21956

Twomey, J., LaGasse, L., Derauf, C., Newman, E., Shah, R., Smith, L., ... & Lester, B. (2013). Prenatal methamphetamine exposure, home environment, and primary caregiver risk factors predict child behavioral problems at 5 years. American Journal of Orthopsychiatry, 83(1), 64-72. doi: 10.1111/ajop.12007

VanderWaal, C. J., Young, R. M., McBride, D. C., Chriqui, J. F., & Terry-McElrath, Y. M. (2013). Smurfing in small toxic meth labs: Impact of state methamphetamine precursor policies. Journal of Policy Practice, 12(3), 231-255. doi: 10.1080/15588742.2013.796214

Zapata, L.B., Hillis, S.D., Marchbanks, P.A., Curtis, K.M. & Lowry, R. (2008). Methamphetamine use is independently associated with recent risky sexual behaviors and adolescent pregnancy. Journal of School Health, 78(12), 641-648. doi: 10.1111/j.1746-1561.2008.00360.x

Prevalence, Intervention and Treatment

Armstrong, T. A., & Armstrong, G. S. (2013). A multivariate analysis of the sociodemographic predictors of methamphetamine production and use. Crime & Delinquency, 59(3), 443-467. doi: 10.1177/0011128709340841

Bairan, A., Boeri, M., & Morian, J. (2014). Methamphetamine use among suburban women: Implications for nurse practitioners. Journal of the American Association of Nurse Practitioners. doi: 10.1002/2327-6924.12107

Bowen, A., Moring, J., Williams, M., Hopper, G., & Daniel, C. (2011). An investigation of bioecological influences associated with first use of methamphetamine in a rural state. The Journal of Rural Health: Official Journal of the American Rural Health Association and the National Rural Health Care Association, 28(3), 286-295. doi: 10.1111/j.1748-0361.2011.00391.x

Brensilver, M., Heinzerling, K. G., & Shoptaw, S. (2013). Pharmacotherapy of amphetamine‐ type stimulant dependence: An update. Drug and alcohol review, 32(5), 449-460. doi: 10.1111/dar.12048

Ciketic, S., Hayatbakhsh, M. R., Doran, C. M., Najman, J. M., & McKetin, R. (2012). A review of psychological and pharmacological treatment options for methamphetamine dependence. Journal of Substance Use, 17(4), 363-383. doi: 10.3109/14659891.2011.592900

Coffin, P. O., Santos, G. M., Das, M., Santos, D. M., Huffaker, S., Matheson, T., ... & Colfax, G. N. (2013). Aripiprazole for the treatment of methamphetamine dependence: A randomized, double‐blind, placebo‐controlled trial. Addiction, 108(4), 751-761. doi: 10.1111/add.12073

Evans, L. (2013). High in the heartland: A look at the regional factors that contribute to methamphetamine addiction in the great plains. In Nelson, A., Graves, J., & Thompson, H. F. (Eds.) The Spanish Northern Plains: A National Conference on the Northern Plains (pp. 52-67). Retrieved from (PDF 1.8MB)

Ghasemi, A., Eftekhari, M., Foroshani, A. R., Tol, A., & Taghdisi, M. H. (2013). Effect of empowerment based intervention program on promoting lifestyle among methamphetamine addict and their families compare with non-addicts. World Applied Sciences Journal, 22(2). doi: 10.5829/idosi.wasj.2013.22.02.353

Gruenewald, P. J., Ponicki, W. R., Remer, L. G., Waller, L. A., Zhu, L., & Gorman, D. M. (2013). Mapping the spread of methamphetamine abuse in California from 1995 to 2008. American journal of public health, 103(7), 1262-1270. doi: 10.2105/AJPH.2012.300779

Hart, C. L., Marvin, C. B., Silver, R., & Smith, E. E. (2012). Is cognitive functioning impaired in methamphetamine users? A critical review. Neuropsychopharmacology, 37(3), 586-608. doi: 10.1038/npp.2011.276

Kerley, K. R., Leban, L., Copes, H., Taylor, L., & Agnone, C. (2014). Methamphetamine using careers of white and black women. Deviant Behavior, 35(6), 477-495. doi: 10.1080/01639625.2013.859046

Korcha, R. A., Polcin, D. L., Evans, K., Bond, J. C., & Galloway, G. P. (2014). Intensive Motivational Interviewing for women with concurrent alcohol problems and methamphetamine dependence. Journal of substance abuse treatment, 46(2), 113-119. Retrieved from

Lecomte, T., Paquin, K., Mueser, K. T., MacEwan, G. W., Goldner, E., Thornton, A. E., ... & Honer, W. G. (2013). Relationships among depression, PTSD, methamphetamine abuse, and psychosis. Journal of Dual Diagnosis, 9(2), 115-122. doi: 10.1080/15504263.2013.778930

Mahaffey, J., Cull, E. A., Aguilera, D., Mouser, T., Poynter, L., & Lyons, A. (2010). Drug endangered children and methamphetamine: A provider tool for identification. Journal of Pediatric Nursing, 25(2), e7-e8.

Marshall, T. A., Cunningham, M., & Guzman-Armstrong, S. (2010). Dietary habits of methamphetamine users. Journal of the American Dietetic Association, 110(9), A44.

Maxwell, J. C. (2013). A new survey of methamphetamine users in treatment: Who they are, w they like “meth,” and why they need additional services. Substance use & misuse. doi:10.3109/10826084.2013.841244

McKenna, S. A. (2014). Navigating the risk environment: Structural vulnerability, sex, and reciprocity among women who use methamphetamine. International Journal of Drug Policy, 25(1), 112-115. Retrieved from

Mooney, L. J., Cooper, C., London, E. D., Chudzynski, J., Dolezal, B., Dickerson, D., ... & Rawson, R. A. (2014). Exercise for methamphetamine dependence: Rationale, design, and methodology. Contemporary clinical trials, 37(1), 139-147. Retrieved from

Rusyniak, D. E. (2013). Neurologic manifestations of chronic methamphetamine abuse. Psychiatric Clinics of North America, 36(2), 261-275. doi: 10.1016/j.psc.2013.02.005

Smout, M. F., Longo, M., Harrison, S., Minniti, R., Wickes, W., & White, J. M. (2010). Psychosocial treatment for methamphetamine use disorders: a preliminary randomized controlled trial of cognitive behavior therapy and acceptance and commitment therapy. Substance Abuse, 31(2), 98-107. doi: 10.1080/08897071003641578

Criminal Justice and Legislation

Dobkin, C. & Nicosia, N. (2009). The War on Drugs: Methamphetamine, public health, and crime. American Economic Review, 99(1), 324-349. doi: 10.1257/aer.99.1.324

Gilbreath, A. H. (2013). A spatial analysis of methamphetamine lab seizures in the Midwest high-intensity drug trafficking area before and after federal precursor legislation. In Leitner, M. (Ed.) Crime Modeling and Mapping Using Geospatial Technologies (pp. 297-316). doi: 10.1007/978-94-007-4997-9_13

Garriott, W. (2013). Policing methamphetamine: Police power and the War on Drugs in a rural US community. In Garriott, W. (Ed.) Policing and Contemporary Governance: The Anthropology of Police in Practice (pp. 53-76). doi: 10.1057/9781137309679.0009

Leukefeld, C., Gullotta, T. P., & Gregrich, J., Eds. (2011). Handbook of Evidence-Based Substance Abuse Treatment in Criminal Justice Settings. New York, NY: Springer.

Linnemann, T. (2013). Governing through meth: Local politics, drug control and the drift toward securitization. Crime, Media, Culture, 9(1), 39-61. doi: 10.1177/1741659012454125

Medhus, S., Holm, B., Mørland, J., & Bramness, J. G. (2013). Association between methamphetamine versus amphetamine and acute psychiatric symptoms. Journal of Dual Diagnosis, 9(4), 292-300. doi: 10.1080/15504263.2013.835161

Melnikova, N., Welles, W. L., Wilburn, R. E., Rice, N., Wu, J., & Stanbury, M. (2011). Hazards of illicit methamphetamine production and efforts at reduction: Data from the hazardous substances emergency events surveillance system. Public Health Reports, 126(Suppl 1), 116. Retrieved from (PDF 706KB)

Nonnemaker, J., Engelen, M., & Shive, D. (2011). Are methamphetamine precursor control laws effective tools to fight the methamphetamine epidemic?.Health economics, 20(5), 519- 531. doi: 10.1002/hec.1610

Omori, M. K. (2013). Moral panics and morality policy the impact of media, political ideology, drug use, and manufacturing on methamphetamine legislation in the United States. Journal of drug issues, 43(4), 517-534. doi: 10.1177/0022042613491101

Vandermause, R., Severtsen, B., & Roll, J. (2013). Re-creating a vision of motherhood: Therapeutic Drug Court and the narrative. Qualitative Social Work, 12(5), 620-636. doi: 10.1177/1473325012447591

Tribal Populations and Methamphetamine

Barlow, A., Mullany, B. C., Neault, N., Davis, Y., Billy, T., Hastings, R., ... & Walkup, J. T. (2010). Examining correlates of methamphetamine and other drug use in pregnant American Indian adolescents. American Indian & Alaska Native Mental Health Research: The Journal of the National Center, 17(1). Retrieved from (PDF 677KB)

Brown, R. A. (2010). Crystal methamphetamine use among American Indian and White youth in Appalachia: Social context, masculinity, and desistance. Addiction research & theory, 18(3), 250-269. doi:10.3109/16066350902802319

De Ravello, L., Everett Jones, S., Tulloch, S., Taylor, M., & Doshi, S. (2014). Substance use and sexual risk behaviors among American Indian and Alaska Native high school students. Journal of school health, 84(1), 25-32. doi: 10.1111/josh.12114

Gilder, D. A., Gizer, I. R., Lau, P., & Ehlers, C. L. (2014). Item Response Theory analyses of DSM-IV and DSM-5 stimulant use disorder criteria in an American Indian community sample. Drug and alcohol dependence, 135, 29-36. Retrieved from

Parker, B. (2013). Methamphetamine use among Native Americans. Multicultural Health Issues: HPEG 58700.

Willis, D. J., & Spicer, P. (2013). American Indian and Alaska Native children and families. In Child and Family Advocacy: Bridging the Gaps Between Research, Practice, and Policy (pp. 191-201). Springer: New York. doi: 10.1007/978-1-4614-7456-2_13

Military and Veteran Families and Children Impacted by Methamphetamine

Acion, L., Ramirez, M. R., Jorge, R. E., & Arndt, S. (2013). Increased risk of alcohol and drug use among children from deployed military families. Addiction, 108(8), 1418-1425. doi: 10.1111/add.12161

Booth, B. M., Davis, T. D., Cheney, A. M., Mengeling, M. A., Torner, J. C., & Sadler, A. G. (2012). Physical health status of female veterans: Contributions of sex partnership and in- military rape. Psychosomatic medicine, 74(9), 916-924. doi: 10.1097/PSY.0b013e31827078e2

Chermack, S. T., Bohnert, A. S., Price, A. M., Austin, K., & Ilgen, M. A. (2011). Substance use disorders and homicide death in veterans. Journal of studies on alcohol and drugs, 73(1), 10. Retrieved from

Ganzini, L. (2013). Comparison of health service use among veterans with methamphetamine versus alcohol use disorders. Journal of Addiction Medicine, 8(1), 47-52. doi: 10.1097/ADM.0000000000000005

Gilreath, T. D., Cederbaum, J. A., Astor, R. A., Benbenishty, R., Pineda, D., & Atuel, H. (2013). Substance use among military-connected youth: The California healthy kids survey. American journal of preventive medicine, 44(2), 150-153. Retrieved from

Glasner-Edwards, S., Mooney, L. J., Ang, A., Hillhouse, M., Rawson, R., & Methamphetamine Treatment Project Corporate Authors. (2013). Does posttraumatic stress disorder affect post-treatment methamphetamine use?. Journal of dual diagnosis, 9(2), 123-128. doi: 10.1080/15504263.2013.779157

Golub, A., & Bennett, A. S. (2014). Substance use over the military–veteran life course: An analysis of a sample of OEF/OIF veterans returning to low-income predominately minority communities. Addictive behaviors, 39(2), 449-454.

Hagedorn, H. J., Noorbaloochi, S., Simon, A. B., Bangerter, A., Stitzer, M. L., Stetler, C. B., & Kivlahan, D. (2013). Rewarding early abstinence in Veterans Health Administration addiction clinics. Journal of substance abuse treatment, 45(1), 109-117. doi:10.1016/j.jsat.2013.01.006

Han, E., Paulus, M. P., Wittmann, M., & Chung, H. (2011). Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals. Journal of Chromatography B, 879(7), 541-547. doi:10.1016/j.jchromb.2011.01.002

Nash, B. S., David, L., Wilkinson, J., Paradis, B., Kelley, S., Naseem, A., & Grant, K. M. (2011). Trauma and substance use disorders in rural and urban veterans. The Journal of Rural Health, 27(2), 151-158. doi: 10.1111/j.1748-0361.2010.00326.x

Rivera, M., & Rabby, M. (2013). Adolescent protective factors of substance use: Comparing youth's responses by their indication of their family's military status. Military Behavioral Health, 1(2), 152-158. doi: 10.1080/21635781.2013.839936

Vazan, P., Golub, A., & Bennett, A. S. (2013). Substance use and other mental health disorders among veterans returning to the inner city: Prevalence, correlates, and rates of unmet treatment need. Substance use & misuse, 48(10), 880-893. doi:10.3109/10826084.2013.796989

Contact Us

The National Center on Substance Abuse and Child Welfare offers free technical assistance to a various of systems on making policy and practice changes to improve outcomes for families affected by substance use disorders and involvement with child welfare services. To learn more about technical assistance services or if you have a question please email NCSACW at or call toll-free at 1–866–493–2758.

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